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Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia by M. Nchito; H. Friis; K.F. Michaelsen; L. Mubila; A. Olsen is a Medicine article available to read on EtoBox.

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Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron and multi-micronutrient (without iron) supplementation trial (Nchito et al., 2004), we determined intestinal permeability in a subgroup of schoolchildren at 10 months' follow-up to assess the effect of the interventions. Among 153 children (mean age 10.2 years and 53.6% girls) iron supplementation resulted in a higher L:M ratio compared with placebo (0.29 vs. 0.21, P=0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal iron supplementation on morbidity found in some other studies.

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Author

M. Nchito; H. Friis; K.F. Michaelsen; L. Mubila; A. Olsen

Publisher

Elsevier Science; Oxford University Press; Oxford University Press (OUP); ScienceOpen (ISSN 0035-9203)

Published

2006

Language

EN

Field

Medicine (Health Sciences)