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Neuroinflammation: The central enabler of postoperative cognitive dysfunction by Yang Liu; Wei Yang; Jinqi Xue; Juntong Chen; Shiqing Liu; Shijie Zhang; Xiaohui Zhang; Xi Gu; Youjing Dong; Peng Qiu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Neuroinflammation: The central enabler of postoperative cognitive dysfunction about?

The proportion of advanced age patients undergoing surgical procedures is on the rise owing to advancements in surgical and anesthesia technologies as well as an overall aging population. As a complication of anesthesia and surgery, older patients frequently suffer from postoperative cognitive dysfunction (POCD), which may persist for weeks, months or even longer. POCD is a complex pathological process involving multiple pathogenic factors, and its mechanism is yet unclear. Potential theories include inflammation, deposition of pathogenic proteins, imbalance of neurotransmitters, and chronic stress. The identification, prevention, and treatment of POCD are still in the exploratory stages owing to the absence of standardized diagnostic criteria. Undoubtedly, comprehending the development of POCD remains crucial in overcoming the illness. Neuroinflammation is the leading hypothesis and a crucial component of the pathological network of POCD and may have complex interactions with other mechanisms. In this review, we discuss the possible ways in which surgery and anesthesia cause neuroinflammation and investigate the connection between neuroinflammation and the development of POCD. Und

Who reads Neuroinflammation: The central enabler of postoperative cognitive dysfunction?

Author

Yang Liu; Wei Yang; Jinqi Xue; Juntong Chen; Shiqing Liu; Shijie Zhang; Xiaohui Zhang; Xi Gu; Youjing Dong; Peng Qiu

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)