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Interaction effect of Alzheimer's disease pathology and education, occupation, and socioeconomic status as a proxy for cognitive reserve on cognitive performance: in vivo positron emission tomography study by Fumihiko Yasuno; Hiroyuki Minami; Hideyuki Hattori; for the Alzheimer's Disease Neuroimaging Initiative is a Medicine article available to read on EtoBox.
What is Interaction effect of Alzheimer's disease pathology and education, occupation, and socioeconomic status as a proxy for cognitive reserve on cognitive performance: in vivo positron emission tomography study about?
## Aim Educational attainment, occupation, and socioeconomic status have been regarded as major factors influencing cognitive reserve (CR). This study aimed to investigate the interaction effect of amyloid‐β/tau burden and education/occupation/socioeconomic status as a proxy for CR on cognitive performance. ## Methods We analyzed the datasets of the Alzheimer's Disease Neuroimaging Initiative. We included clinically normal subjects and patients with mild cognitive impairment or Alzheimer's disease who had undergone a florbetapir scan within 1 year of a flortaucipir (AV‐1451) scan (n = 127). Partial correlation analysis between the standardized uptake value ratio of florbetapir/AV‐1451 and the proxy for CR was performed with the 13‐item Alzheimer's Disease Assessment Scale‐cognitive subscale (ADAS‐cog) score as a covariate. Stepwise multiple linear regression analysis was performed to determine the predictors of ADAS‐cog performance based on the interaction between the imaging biomarkers and the proxy for CR. ## Results We found a significant positive partial correlation between educational level and tau pathology in Braak stage 1/2 areas, and we observed significantly higher tau ac
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- Author
- Fumihiko Yasuno; Hiroyuki Minami; Hideyuki Hattori; for the Alzheimer's Disease Neuroimaging Initiative
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1346-3500)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)