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Radiosurgery With or Without A 2-mm Margin for 93 Single Brain Metastases by François Nataf; Michel Schlienger; Zhihua Liu; Jean Noel Foulquier; Benoit Grès; Alexandre Orthuon; Jean Michel Vannetzel; Bernard Escudier; Jean- François Meder; François Xavier Roux; Emmanuel Touboul is a Medicine article available to read on EtoBox.

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## Purpose: Retrospective comparison of linac radiosurgery (rs) in 93 single brain metastases with or without a 2-mm margin. ## Patients and methods: A total of 153 patients had linac rs (between april 1992 and june 2004), with 139 patients (90.8%) evaluable in june 2005. sixty-one patients (44%) had extracranial lesions and 65 patients had neurologic symptoms (47%). rs alone: 105 patients (66%); rs +whole brain radiotherapy: 34 patients (24%). single metastasis: 93/139 patients; classic rs: 42/93 patients; 2-mm margin: 51/93 patients; 30 multiple lesions patients were excluded. ## Treatment: 15 mv x-ray linac, circular minibeams, 8-30 mm, four to six noncoplanar coronal arcs. isodose was 60-80%; doses were 10-20 gy. ## Follow-up: 12 months-13 years; median, 14 months. ## Results: Local control (lc) was not improved in 51 margin patients vs. 42 classic rs patients: 1 year: 69.1% and 72.4%. two-year lc rate: 64% and 54.7%, respectively. survival: median classic rs: 11.3 months; margin rs, 19 months (p = 0.34) and 1 year, 41.6% and 60.2%, respectively. margin rs patients had a significantly higher rate of severe parenchymal complications: 19.6% vs. 7.1% (p = 0.02); surgery was necess

Who reads Radiosurgery With or Without A 2-mm Margin for 93 Single Brain Metastases?

Author

François Nataf; Michel Schlienger; Zhihua Liu; Jean Noel Foulquier; Benoit Grès; Alexandre Orthuon; Jean Michel Vannetzel; Bernard Escudier; Jean- François Meder; François Xavier Roux; Emmanuel Touboul

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2008

Language

EN

Field

Medicine (Health Sciences)