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Oxidative stress in Caenorhabditis elegans : protective effects of superoxide dismutase/catalase mimetics by James N. Sampayo; Anders Olsen; Gordon J. Lithgow is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Oxidative stress in Caenorhabditis elegans : protective effects of superoxide dismutase/catalase mimetics about?

## Summary The lifespan of __Caenorhabditis elegans__ can be extended by the administration of synthetic superoxide dismutase/catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk‐134 and Euk‐8, confer resistance to the oxidative stress‐inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF‐I‐like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.

Who reads Oxidative stress in Caenorhabditis elegans : protective effects of superoxide dismutase/catalase mimetics?

Author

James N. Sampayo; Anders Olsen; Gordon J. Lithgow

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 1474-9718)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)