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Measurement of Absolute Values of Hemoglobin Oxygenation in the Brain of Small Rodents by Near Infrared Reflection Spectrophotometry by Nikolaus Plesnila; Christiane Putz; Markus Rinecker; Joachim Wiezorrek; Ludwig Schleinkofer; Alwin E Goetz; Wolfgang M Kuebler is a Neuroscience article available to read on EtoBox.

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Reflection near infrared spectroscopy (reNIRS) has been proposed as a novel technique for the measurement of absolute values of total hemoglobin (tHb), oxygenated hemoglobin (oxHb), hemoglobin saturation (SO 2 ), and cytochrome aa 3 oxidation status (oxCyt aa 3 ) in living tissue. In this study, we evaluated reNIRS during physiological cerebral blood flow conditions in rats (n =6) and during the induction of global cerebral ischemia in gerbils (n= 6). ReNIRS parameters were assessed over the exposed cerebral cortex and compared to regional cerebral blood flow (rCBF) data obtained by laser Doppler flowmetry. Under physiological conditions, reNIRS measurements reflected the large intra-and interindividual variability of oxHb and tHb in the brain. The absolute values obtained by reNIRS for tHb (6.3 91.7 mg/ml), oxHb (3.7 9 1.1 mg/ml), and SO 2 (6195%) matched expected values. In contrast, measurements of oxCyt aa 3 were unstable and results unreliable. reNIRS reliably detected cerebral ischemia, verified by a reduction of rCBF to 11% of baseline. tHb dropped to 74 97% of baseline (PB 0.001), reflecting ischemic microvascular vasoconstriction. oxHb and SO 2 dropped to expected near-zer

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Author

Nikolaus Plesnila; Christiane Putz; Markus Rinecker; Joachim Wiezorrek; Ludwig Schleinkofer; Alwin E Goetz; Wolfgang M Kuebler

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-0270)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)