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Hypothermia inhibits translocation of CaM kinase II and PKC-α, β, γ isoforms and fodrin proteolysis in rat brain synaptosome during ischemia-reperfusion by Kazuki Harada; Tsuyoshi Maekawa; Ryosuke Tsuruta; Tadashi Kaneko; Daikai Sadamitsu; Tetsumori Yamashima; Ken-ichi Yoshida is a Neuroscience article available to read on EtoBox.

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## Abstract To clarify the involvement of intracellular signaling pathway and calpain in the brain injury and its protection by mild hypothermia, immunoblotting analyses were performed in the rat brain after global forebrain ischemia and reperfusion. After 30 min of ischemia followed by 60 min of reperfusion, Ca^2+^/calmodulin‐dependent kinase II (CaM kinase II) and protein kinase C (PKC)‐α, β, γ isoforms translocated to the synaptosomal fraction, while mild hypothermia (32°C) inhibited the translocation. The hypothermia also inhibited fodrin proteolysis caused by ischemia‐reperfusion, indicating the inhibition of calpain. These effects of hypothermia may explain the mechanism of the protection against brain ischemia‐reperfusion injury through modulating synaptosomal function. © 2002 Wiley‐Liss, Inc.

Who reads Hypothermia inhibits translocation of CaM kinase II and PKC-α, β, γ isoforms and fodrin proteolysis in rat brain synaptosome during ischemia-reperfusion?

Author

Kazuki Harada; Tsuyoshi Maekawa; Ryosuke Tsuruta; Tadashi Kaneko; Daikai Sadamitsu; Tetsumori Yamashima; Ken-ichi Yoshida

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)