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Input-output Organization of the Mouse Claustrum by Brian Zingg; Hong-Wei Dong; Huizhong Whit Tao; Li I. Zhang is a Neuroscience article available to read on EtoBox.

What is Input-output Organization of the Mouse Claustrum about?

Progress in determining the precise organization and function of the claustrum (CLA) has been hindered by the difficulty in reliably targeting these neurons. To overcome this, we used a projection-based targeting strategy to selectively label CLA principal neurons. Combined with adeno-associated virus (AAV) and monosynaptic rabies tracing techniques, we systematically examined the pre-synaptic input and axonal output of this structure. We found that CLA neurons projecting to retrosplenial cortex (RSP) collateralize extensively to innervate a variety of higher-order cortical regions. No subcortical labeling was found, with the exception of sparse terminals in the basolateral amygdala (BLA). This pattern of output was similar to cingulate- and visual cortex-projecting CLA neurons, suggesting a common targeting scheme among these projection-defined populations. Rabies virus tracing directly demonstrated widespread synaptic inputs to RSP-projecting CLA neurons from both cortical and subcortical areas. The strongest inputs arose from classically defined limbic regions, including medial prefrontal cortex, anterior cingulate, BLA, ventral hippocampus, and neuromodulatory systems such as t

Who reads Input-output Organization of the Mouse Claustrum?

Author

Brian Zingg; Hong-Wei Dong; Huizhong Whit Tao; Li I. Zhang

Published

2018

Language

EN

Field

Neuroscience (Life Sciences)