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Terpenes on Rhipicephalus (Boophilus) microplus: Acaricidal activity and acetylcholinesterase inhibition by Cardoso, Alana dos Santos; Santos, Everton Gomes Guimarães; Lima, Aldilene da Silva; Temeyer, Kevin B.; Pérez de León, Adalberto A.; Costa, Livio Martins; Soares, Alexandra Martins dos Santos is a Immunology and Microbiology article available to read on EtoBox.

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The Rhipicephalus (Boophilus) microplus tick is the main ectoparasite of cattle in tropical and subtropical regions worldwide. Resistance to chemical acaricides has become widespread affirming the need for new drugs to tick control. Terpenes have become a promising alternative for cattle tick control, however the mechanism of action of these compounds is still controversial. Inhibition of acetylcholinesterase (AChE) is a well established mechanism of action of organophosphate and carbamate acaricides, but the possible action of terpenes on tick AChEs has seldom been studied in resistant and sensitive strains of R. (B.) microplus. The aim of the present study was to evaluate terpene inhibition of AChE from resistant and sensitive strains of R. (B.) microplus in correlation with their acaricidal activity. Among the terpenes used in the present study, p-cymene, thymol, carvacrol, and citral displayed acaricidal activity with LC of 1.75, 1.54, 1.41, and 0.38 mg.mL for the susceptible strain, and LC of 1.40, 1.81, 1.10, and 1.13 mg.mL for the resistant strain. Thymol and carvacrol inhibited the AChE of the susceptible strain larvae with IC of 0.93 and 0.04 mg.mL, respectively. The IC ex

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Author

Cardoso, Alana dos Santos; Santos, Everton Gomes Guimarães; Lima, Aldilene da Silva; Temeyer, Kevin B.; Pérez de León, Adalberto A.; Costa, Livio Martins; Soares, Alexandra Martins dos Santos

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)