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Polymorphism at the defensin gene in the Anopheles gambiae complex: Testing different selection hypotheses by Frédéric Simard; Monica Licht; Nora J. Besansky; Tovi Lehmann is a Medicine article available to read on EtoBox.

What is Polymorphism at the defensin gene in the Anopheles gambiae complex: Testing different selection hypotheses about?

Genetic variation in defensin, a gene encoding a major effector molecule of insects immune response was analyzed within and between populations of three members of the Anopheles gambiae complex. The species selected included the two anthropophilic species, An. gambiae and An. arabiensis and the most zoophilic species of the complex, An. quadriannulatus. The first species was represented by four populations spanning its extreme genetic and geographical ranges, whereas each of the other two species was represented by a single population. We found (i) reduced overall polymorphism in the mature peptide region and in the total coding region, together with specific reductions in rare and moderately frequent mutations (sites) in the coding region compared with non-coding regions, (ii) markedly reduced rate of non-synonymous diversity compared with synonymous variation in the mature peptide and virtually identical mature peptide across the three species, and (iii) increased divergence between species in the mature peptide together with reduced differentiation between populations of An. gambiae in the same DNA region. These patterns suggest a strong purifying selection on the mature peptide

Who reads Polymorphism at the defensin gene in the Anopheles gambiae complex: Testing different selection hypotheses?

Author

Frédéric Simard; Monica Licht; Nora J. Besansky; Tovi Lehmann

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)

Published

2007

Language

EN

Field

Medicine (Health Sciences)