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Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen by Laurent M.A. Favié; Alwin D.R. Huitema; Marcel P.H. Broek; Carin M.A. Rademaker; Timo R. Haan; Henrica L.M. Straaten; Sinno H.P. Simons; Monique Rijken; Debbie H.G.M. Nuytemans; Toine C.G. Egberts; Floris Groenendaal is a Medicine article available to read on EtoBox.
What is Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen about?
## Aims Lidocaine is used to treat neonatal seizures refractory to other anticonvulsants. It is effective, but also associated with cardiac toxicity. Previous studies have reported on the pharmacokinetics of lidocaine in preterm and term neonates and proposed a dosing regimen for effective and safe lidocaine use. The objective of this study was to evaluate the previously developed pharmacokinetic models and dosing regimen. As a secondary objective, lidocaine effectiveness and safety were assessed. ## Methods Data from preterm neonates and (near‐)term neonates with and without therapeutic hypothermia receiving lidocaine were included. Pharmacokinetic analyses were performed using non‐linear mixed effects modelling. Simulations were performed to evaluate the proposed dosing regimen. Lidocaine was considered effective if no additional anticonvulsant was required and safe if no cardiac adverse events occurred. ## Results Data were available for 159 neonates; 50 (31.4%) preterm and 109 term neonates, of whom 49 (30.8%) were treated with therapeutic hypothermia. Lidocaine clearance increased with postmenstrual age by 0.69%/day (95% confidence interval 0.54–0.84%). During therapeutic hypo
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- Author
- Laurent M.A. Favié; Alwin D.R. Huitema; Marcel P.H. Broek; Carin M.A. Rademaker; Timo R. Haan; Henrica L.M. Straaten; Sinno H.P. Simons; Monique Rijken; Debbie H.G.M. Nuytemans; Toine C.G. Egberts; Floris Groenendaal
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)