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Can I read Induction of a Neoarthrosis by Precisely Controlled Motion in an Experimental Mid‐femoral Defect on EtoBox?
Induction of a Neoarthrosis by Precisely Controlled Motion in an Experimental Mid‐femoral Defect by Dennis M. Cullinane; Amy Fredrick; Solomon R. Eisenberg; Donna Pacicca; Michael V. Elman; Cassandra Lee; Kristy Salisbury; Louis C. Gerstenfeld; Thomas A. Einhorn is a Medicine article available to read on EtoBox.
What is Induction of a Neoarthrosis by Precisely Controlled Motion in an Experimental Mid‐femoral Defect about?
## Abstract Bone regeneration during fracture healing has been demonstrated repeatedly, yet the regeneration of articular cartilage and joints has not yet been achieved. It has been recognized however that the mechanical environment during fracture healing can be correlated to the contributions of either the endochondral or intramembranous processes of bone formation, and to resultant tissue architecture. Using this information, the goal of this study was to test the hypothesis that induced motion can directly regulate osteogenic and chondrogenic tissue formation in a rat mid‐femoral bone defect and thereby influence the anatomical result. Sixteen male Sprague Dawley rats (400 ± 20 g) underwent production of a mid‐diaphyseal, non‐critical sized 3.0 mm segmental femoral defect with rigid external fixation using a custom designed four pin fixator. One group of eight animals represented the controls and underwent surgery and constant rigid fixation. In the treatment group the custom external fixator was used to introduce daily interfragmentary bending strain in the eight treatment animals (12°s angular excursion), with a hypothetical symmetrical bending load centered within the gap. T
Who reads Induction of a Neoarthrosis by Precisely Controlled Motion in an Experimental Mid‐femoral Defect?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dennis M. Cullinane; Amy Fredrick; Solomon R. Eisenberg; Donna Pacicca; Michael V. Elman; Cassandra Lee; Kristy Salisbury; Louis C. Gerstenfeld; Thomas A. Einhorn
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)