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Can I read Lipocalin 2 Stimulates Bone Fibroblast Growth Factor 23 Production in Chronic Kidney Disease on EtoBox?
Lipocalin 2 Stimulates Bone Fibroblast Growth Factor 23 Production in Chronic Kidney Disease by Guillaume Courbon; Connor Francis; Claire Gerber; Samantha Neuburg; Xueyan Wang; Emily Lynch; Tamara Isakova; Jodie L. Babitt; Myles Wolf; Aline Martin; Valentin David is a Medicine article available to read on EtoBox.
What is Lipocalin 2 Stimulates Bone Fibroblast Growth Factor 23 Production in Chronic Kidney Disease about?
Bone-produced fibroblast growth factor 23 (FGF23) increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin 2; LCN2 the murine homolog) is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression. We investigated bone FGF23 regulation by circulating LCN2. At 23 weeks, Col4a3^KO^ mice showed impaired kidney function, increased levels of kidney and serum LCN2, increased bone and serum FGF23, anemia, and left ventricular hypertrophy (LVH). Deletion of __Lcn2__ in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23. __Lcn2__ deletion specifically prevented FGF23 elevations in response to inflammation, but not iron deficiency or phosphate, and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating __Fgf23__ transcription via activation of cAMP-mediated signaling in bone cells. These results show that kidney-produced LCN2 is an important mediator
Who reads Lipocalin 2 Stimulates Bone Fibroblast Growth Factor 23 Production in Chronic Kidney Disease?
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- Author
- Guillaume Courbon; Connor Francis; Claire Gerber; Samantha Neuburg; Xueyan Wang; Emily Lynch; Tamara Isakova; Jodie L. Babitt; Myles Wolf; Aline Martin; Valentin David
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)