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Synthesis of 2‐imino‐7‐methyl‐2,3‐dihydroimidazo[1,2‐ a ]‐pyrimidin‐5(1 H )‐ones and their reactions with nucleophiles by Virginija Jakubkiene; Zana Kacnova; Milda M. Burbuliene; Povilas Vainilavicius is a Chemistry article available to read on EtoBox.

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## Abstract magnified image [2‐Alkylthio‐6‐methyl‐4‐oxopyrimidin‐3(4__H__)‐yl]acetonitriles (**3‐5**) treated with sodium methoxide in methanol followed by ammonium chloride were cyclized to 2‐imino‐7‐methyl‐2,3‐dihydroimidazo[1,2‐__a__]‐pyrimidin‐5(1__H__)‐ones (**6‐8**). Under acid or base‐catalyzed hydrolysis they were converted to 7‐methyl‐imidazo[1,2‐__a__]pyrimidine‐2,5‐[1__H__,3__H__]‐diones (**9‐11**), whereas in the reaction with butyl‐ or benzylamine the corresponding 7‐methyl‐2‐(substitutedamino)imidazo[1,2‐__a__]pyrimidin‐5(3__H__)‐ones (**13‐18**) were produced. The latter were found to exist in two tautomeric forms in CDCl~3~ solution.

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Author

Virginija Jakubkiene; Zana Kacnova; Milda M. Burbuliene; Povilas Vainilavicius

Publisher

Journal of Heterocyclic Chemistry; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 0022-152X)

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)