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Can I read Immune checkpoint blockers in patients with unresectable or metastatic thymic epithelial tumours: A meta-analysis on EtoBox?
Immune checkpoint blockers in patients with unresectable or metastatic thymic epithelial tumours: A meta-analysis by Jordi Remon; Guillermo Villacampa; Francesco Facchinetti; Massimo Di Maio; Florit Marcuse; Marcello Tiseo; Monique Hochstenbag; Lizza E.L. Hendriks; Benjamin Besse is a Medicine article available to read on EtoBox.
What is Immune checkpoint blockers in patients with unresectable or metastatic thymic epithelial tumours: A meta-analysis about?
Background For patients with advanced thymic epithelial tumours (TET), there is no standard second-line treatment after platinum-based chemotherapy. Although immune checkpoint blockers (ICB) are a potential treatment strategy, their efficacy seems limited with an increased risk of immune-related adverse events (ir-AEs), thus hampering their application in daily clinical practice. Methods We performed a meta-analysis to better evaluate the existing evidence about the activity and safety of ICB in the setting of unresectable or metastatic advanced TET previously treated with platinum-based chemotherapy. Results Six phase I/II trials met the eligibility criteria including a total of 166 evaluable patients (77% thymic carcinoma, 23% thymoma) evaluable for activity after being treated with pembrolizumab, nivolumab, avelumab or atezolizumab. The overall response rate to ICB was 18.4% (95% CI: 12.3–26.5), and the one-year progression-free survival rate and one-year overall survival rate were 26.0% (95% CI: 19.6–34.6) and 66.9% (95% CI: 59.6–75.2%), respectively. The incidence of grade 3–5 ir-AEs was 26.4%, with 17.1% in thymic carcinoma and 58.3% in thymoma. Conclusions Despite the absenc
Who reads Immune checkpoint blockers in patients with unresectable or metastatic thymic epithelial tumours: A meta-analysis?
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- Author
- Jordi Remon; Guillermo Villacampa; Francesco Facchinetti; Massimo Di Maio; Florit Marcuse; Marcello Tiseo; Monique Hochstenbag; Lizza E.L. Hendriks; Benjamin Besse
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)