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Role of FDG PET/CT in monitoring treatment response in patients with invasive fungal infections by Alfred O. Ankrah; Lambert F. R. Span; Hans C. Klein; Pim A. de Jong; Rudi A. J. O. Dierckx; Thomas C. Kwee; Mike M. Sathekge; Andor W. J. M. Glaudemans is a Medicine article available to read on EtoBox.
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Introduction Invasive fungal infections (IFIs) occur mostly in immunosuppressed patients and can be life-threatening. Inadequate treatment is associated with high morbidity and mortality. We examined the role of 2-fluorodeoxyglucose positron emission tomography integrated with CT (FDG-PET/CT) in monitoring IFIs and therapy decision-making, and evaluated the role of baseline metabolic parameters in predicting the metabolic response. Methods All patients between October 2009 and March 2018, diagnosed with IFIs, treated with antifungal drugs, and who underwent FDG-PET/CT at baseline and at one or more timepoints during treatment were retrospectively included. The electronic patient files were reviewed for pathology, microbiology, and laboratory findings. All FDG-PET/CT scans were performed according to standardized European Association of Nuclear Medicine/EANM Research Limited (EANM/EARL) protocols. For each scan, the global total lesion glycolysis (TLG) and metabolic volume (MV), highest maximum standardized uptake value (SUVmax), and peak standardized uptake value (SUVpeak) were determined. The role of FDG-PET/CT on monitoring antifungal therapy was assessed by looking at the clinic
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- Author
- Alfred O. Ankrah; Lambert F. R. Span; Hans C. Klein; Pim A. de Jong; Rudi A. J. O. Dierckx; Thomas C. Kwee; Mike M. Sathekge; Andor W. J. M. Glaudemans
- Publisher
- Springer Science and Business Media LLC
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)