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Peak Concentrations of Ustekinumab After Intravenous Induction Therapy Identify Patients With Crohn’s Disease Likely to Achieve Endoscopic and Biochemical Remission by Jurij Hanžel; Jurij Zdovc; Tina Kurent; Nejc Sever; Katarina Javornik; Katja Tuta; Matic Koželj; Nataša Smrekar; Gregor Novak; Borut Štabuc; Erwin Dreesen; Debby Thomas; Tomaž Vovk; Iztok Grabnar; David Drobne is a Medicine article available to read on EtoBox.

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## Background & aims: Little is known about the relationship between ustekinumab exposure during the first 2 weeks of treatment and outcomes of patients with crohn's disease (cd). we investigated the relationship between serum concentrations of ustekinumab during the first 2 weeks of treatment and endoscopic and biochemical remission in patients with cd. ## Methods: In a prospective observational study, we measured concentrations of ustekinumab in serum samples from 41 consecutive patients who started treatment with ustekinumab (approximately 6 mg/kg, intravenously, then 90 mg every 8 weeks), due to endoscopic markers of active cd, at a single center from october 2017 through january 2019. we measured ustekinumab exposure parameters during the first 2 weeks (peak concentration measured immediately after intravenous infusion, week 2 concentration, and area under the curve through week 2). we investigated the correlation between these parameters and endoscopic remission (simple endoscopic score for cd scores of 3 or less without ulceration, assessed centrally) and biochemical remission (level of fecal calprotectin below 100 mg/kg) using the mann-whitney u test. ## Results: Endoscopic

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Author

Jurij Hanžel; Jurij Zdovc; Tina Kurent; Nejc Sever; Katarina Javornik; Katja Tuta; Matic Koželj; Nataša Smrekar; Gregor Novak; Borut Štabuc; Erwin Dreesen; Debby Thomas; Tomaž Vovk; Iztok Grabnar; David Drobne

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1542-3565)

Published

2020

Language

EN

Field

Medicine (Health Sciences)