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Can I read Characterization of experimental Shuni virus infection in the mouse on EtoBox?
Characterization of experimental Shuni virus infection in the mouse by Angele Breithaupt; Franziska Sick; Natalia Golender; Martin Beer; Kerstin Wernike is a Medicine article available to read on EtoBox.
What is Characterization of experimental Shuni virus infection in the mouse about?
Shuni virus (SHUV), an orthobunyavirus of the Simbu serogroup, was initially isolated in Nigeria in the 1960s, further detected in other African countries and in the Middle East, and is now endemic in Israel. Transmitted by blood-sucking insects, SHUV infection is associated with neurological disease in cattle and horses, and with abortion, stillbirth, or the birth of malformed offspring in ruminants. Surveillance studies also indicated a zoonotic potential. This study aimed to test the susceptibility of the well-characterized interferon (IFN)-α/β receptor knock-out mouse model (Ifnar -/-), to identify target cells, and to describe the neuropathological features. Ifnar -/-mice were subcutaneously infected with two different SHUV strains, including a strain isolated from the brain of a heifer showing neurological signs. The second strain represented a natural deletion mutant exhibiting a loss of function of the S-segment-encoded nonstructural protein NSs, which counteracts the host's IFN response. Here it is shown that Ifnar -/-mice are susceptible to both SHUV strains and can develop fatal disease. Histological examination confirmed meningoencephalomyelitis in mice as described in
Who reads Characterization of experimental Shuni virus infection in the mouse?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Angele Breithaupt; Franziska Sick; Natalia Golender; Martin Beer; Kerstin Wernike
- Publisher
- SAGE Publications
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)