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Paraoxonase gene cluster is a genetic marker for early microvascular complications in Type 1 diabetes by Y. Kao; K. C. Donaghue; A. Chan; B. H. Bennetts; J. Knight; M. Silink is a Medicine article available to read on EtoBox.

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## Abstract **Background** Paraoxonase is a serum enzyme, which prevents oxidation of low‐density lipoprotein (LDL) by hydrolyzing lipid peroxides. Two polymorphisms in __PON1__ gene have been associated with cardiovascular and microvascular diseases in both diabetic and non‐diabetic patients. **Aims** The current project was designed to investigate the association between the polymorphisms of two __PON__ genes and diabetes microvascular diseases (retinopathy and microalbuminuria) and any potential linkage between Met54Leu of __PON1__ and Cys311Ser of __PON2__ gene. **Methods** Diabetic retinopathy and albumin excretion rate were assessed in 372 adolescents with Type 1 diabetes who were genotyped for the two polymorphisms. **Results** We confirmed the increased susceptibility for diabetic retinopathy for the Leu/Leu genotype (odds ratio (OR) 3.34 (confidence interval (CI) 1.95, 5.75), __P__ < 0.0001). The Ser/Ser genotype was significantly more common in those patients with microalbuminuria (albumin excretion rate ≥ 20 μg/min) compared with those with albumin excretion rate < 20 μg/min (OR 4.72 (CI 2.65, 8.41), __P__ < 0.0001). The Ser311 of __PON2__ was in strong linkage disequili

Who reads Paraoxonase gene cluster is a genetic marker for early microvascular complications in Type 1 diabetes?

Author

Y. Kao; K. C. Donaghue; A. Chan; B. H. Bennetts; J. Knight; M. Silink

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)

Published

2002

Language

EN

Field

Medicine (Health Sciences)