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Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain by Anne Monique Nuyt; Zsolt Lenkei; Miklos Palkovits; Pierre Corvol; Catherine Llorens-Cortés is a Neuroscience article available to read on EtoBox.

What is Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain about?

Recent studies have provided evidence for a specific role of the angiotensin II type 2 receptor (AT2) in in vitro neuron differentiation, and in AT2 knock-out mice that display central neurological anomalies. The role of AT2 in brain development is currently unknown. By using radiolabeled cRNA probes for in situ hybridization histochemistry, we determined the ontogenic development of AT2 mRNA in fetal and neonatal rat brain, from 11 days of gestation (E11) to 28 days postnatal (P28). Brain AT2 mRNA is first detected in the lateral hypothalamic neuroepithelium at E13. AT2 mRNA is detected beginning at E15 in the subthalamic and hypoglossus nuclei; at E17 in the pedunculopontine nucleus, cerebellum, motor facial nucleus, and the inferior olivary complex; at E19 in the thalamus, bed nucleus of the supraoptic decussation, interstitial nucleus of Cajal, nuclei of the lateral lemniscus, locus coeruleus, and supragenual nucleus; and at E21 in the lateral septal and medial amygdaloid nuclei, medial geniculate body, and the superior colliculus. The substantia nigra and many telencephalic and medullary nuclei express AT2 mRNA only after birth. Certain structures express AT2 mRNA strongly but

Who reads Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain?

Author

Anne Monique Nuyt; Zsolt Lenkei; Miklos Palkovits; Pierre Corvol; Catherine Llorens-Cortés

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1999

Language

EN

Field

Neuroscience (Life Sciences)