Opening book details…
Can I read Muscle and Adipose Wasting despite Disease Control: Unaddressed Side Effects of Palliative Chemotherapy for Pancreatic Cancer on EtoBox?
Muscle and Adipose Wasting despite Disease Control: Unaddressed Side Effects of Palliative Chemotherapy for Pancreatic Cancer by Pamela N. Klassen; Vickie Baracos; Sunita Ghosh; Lisa Martin; Michael B. Sawyer; Vera C. Mazurak is a Medicine article available to read on EtoBox.
What is Muscle and Adipose Wasting despite Disease Control: Unaddressed Side Effects of Palliative Chemotherapy for Pancreatic Cancer about?
## Simple Summary Muscle and fat losses during chemotherapy for advanced pancreatic cancer are highly prevalent and associated with tumour progression during treatment. Whether chemotherapy treatment also drives these losses is unknown. This retrospective study aimed to define the effects of chemotherapy and tumour progression on muscle and fat loss and determine the relevance of these losses to overall survival. In a cohort of 210 patients over a standardised scan interval, we demonstrated that tumour progression was associated with greater loss of each tissue compared to tumour control. Furthermore, fluorouracil-based triplet chemotherapy was associated with more muscle loss, while gemcitabine-based doublet chemotherapy was associated with more fat loss. Independent of tumour response, patients with the most muscle or fat loss by tertiles had 72–73% greater hazard of death compared to those with the smallest losses. Muscle and adipose losses are adverse effects of chemotherapy treatment that require targeted management strategies. ## Abstract Muscle and adipose wasting during chemotherapy for advanced pancreatic cancer (aPC) are associated with poor outcomes. We aimed to quantify
Who reads Muscle and Adipose Wasting despite Disease Control: Unaddressed Side Effects of Palliative Chemotherapy for Pancreatic Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Pamela N. Klassen; Vickie Baracos; Sunita Ghosh; Lisa Martin; Michael B. Sawyer; Vera C. Mazurak
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)