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Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation by Sezaki, Maiko; Hayashi, Yoshikazu; Wang, Yuxin; Johansson, Alban; Umemoto, Terumasa; Takizawa, Hitoshi is a Immunology and Microbiology article available to read on EtoBox.

What is Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation about?

Lifelong blood production is maintained by bone marrow (BM)-residing hematopoietic stem cells (HSCs) that are defined by two special properties: multipotency and self-renewal. Since dysregulation of either may lead to a differentiation block or extensive proliferation causing dysplasia or neoplasia, the genomic integrity and cellular function of HSCs must be tightly controlled and preserved by cell-intrinsic programs and cell-extrinsic environmental factors of the BM. The BM had been long regarded an immune-privileged organ shielded from immune insults and inflammation, and was thereby assumed to provide HSCs and immune cells with a protective environment to ensure blood and immune homeostasis. Recently, accumulating evidence suggests that hemato-immune challenges such as autoimmunity, inflammation or infection elicit a broad spectrum of immunological reactions in the BM, and in turn, influence the function of HSCs and BM environmental cells. Moreover, in analogy with the emerging concept of “trained immunity”, certain infection-associated stimuli are able to train HSCs and progenitors to produce mature immune cells with enhanced responsiveness to subsequent challenges, and in some

Who reads Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation?

Author

Sezaki, Maiko; Hayashi, Yoshikazu; Wang, Yuxin; Johansson, Alban; Umemoto, Terumasa; Takizawa, Hitoshi

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-3224)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)