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Cu(II) transfer into apo-Cu2Zn2-superoxide dismutase from Cu-thionein oxidized by activated leukocytes by Hans-Jürgen Hartmann; Thomas Schechinger; Ulrich Weser is a Chemistry article available to read on EtoBox.
What is Cu(II) transfer into apo-Cu2Zn2-superoxide dismutase from Cu-thionein oxidized by activated leukocytes about?
The leukocyte-induced oxidative cleavage of yeast &(I)-thionein was examined. Oxidation was followed by the progressive decline of the specific Cotton bands attributed to the Cu(I)-thiolate chromophores between 400 and 270 nm. Despite many potent and competitive copper binding sites certainly present in leukocytes, the reconstitution of apo-CuzZn,-superoxide dismutase was expected due to its higher thermodynamic stability. Both enzymic activity measurements and characteristic Cu(I1) EPR\*\* properties of Cu,Zn,-superoxide dismutase supported a successful reconstitution. The most favoured pathway for releasing Cu(I1) from Cu-thionein was suggested to be an enzymecontrolled oxidation.
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- Author
- Hans-Jürgen Hartmann; Thomas Schechinger; Ulrich Weser
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0020-1693)
- Published
- 1987
- Language
- EN
- Field
- Chemistry (Physical Sciences)