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Can I read Non-linkage of the Glucagon-like Peptide 1 Receptor Gene with Maturity Onset Diabetes of the Young on EtoBox?
Non-linkage of the Glucagon-like Peptide 1 Receptor Gene with Maturity Onset Diabetes of the Young by Y. Zhang; J. T. E. Cook; A. T. Hattersley; R. Firth; P. J. Saker; M. Warren-Perry; M. Stoffel; R. C. Turner is a Medicine article available to read on EtoBox.
What is Non-linkage of the Glucagon-like Peptide 1 Receptor Gene with Maturity Onset Diabetes of the Young about?
Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from beta cells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations may induce the impaired insulin response that is a characteristic feature of NIDDM. To study the relationship between the GLP-1 receptor gene and NIDDM, linkage of a microsatellite polymorphism flanking the GLP-1 receptor gene with diabetes was investigated in three Caucasian families with MODY and in the nuclear families of 12 NIDDM probands. A cumulative LOD score -8.50 excludes linkage in these MODY pedigrees. A LOD score of -1.24 in the NIDDM nuclear pedigrees makes linkage improbable. Mutations in or near the GLP-1 receptor gene are unlikely to be the major cause of the inherited predisposition to NIDDM in Caucasian pedigrees, but we cannot exclude a role for this locus in a polygenic model or a major role in some pedigrees.
Who reads Non-linkage of the Glucagon-like Peptide 1 Receptor Gene with Maturity Onset Diabetes of the Young?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Y. Zhang; J. T. E. Cook; A. T. Hattersley; R. Firth; P. J. Saker; M. Warren-Perry; M. Stoffel; R. C. Turner
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0012-186X)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)