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tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis by Sunyang Ying; Pengcheng Li; Jiaqiang Wang; Kaiqiong Chen; Yu Zou; Moyu Dai; Kai Xu; Guihai Feng; Changjian Zhang; Haiping Jiang; Wei Li; Ying Zhang; Qi Zhou is a Medicine article available to read on EtoBox.
What is tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis about?
tsRNAs (tRNA-derived small RNAs), as products of the stress response, exert considerable influence on stress response and injury regulation. However, it remains largely unclear whether tsRNAs can ameliorate liver injury. Here, we demonstrate the roles of tsRNAs in alleviating liver injury by utilizing the loss of __NSun2__ (NOP2/Sun domain family, member 2) as a tsRNAs-generating model. Mechanistically, the loss of __NSun2__ reduces methyluridine-U5 (m^5^U) and cytosine-C5 (m^5^C) of tRNAs, followed by the production of various tsRNAs, especially Class I tsRNAs (tRF-1s). Through further screening, we show that tRF-Gln-CTG-026 (tG026), the optimal tRF-1, ameliorates liver injury by repressing global protein synthesis through the weakened association between TSR1 (pre-rRNA-processing protein TSR1 homolog) and pre-40S ribosome. This study indicates the potential of tsRNA-reduced global protein synthesis in liver injury and repair, suggesting a potential therapeutic strategy for liver injury.
Who reads tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sunyang Ying; Pengcheng Li; Jiaqiang Wang; Kaiqiong Chen; Yu Zou; Moyu Dai; Kai Xu; Guihai Feng; Changjian Zhang; Haiping Jiang; Wei Li; Ying Zhang; Qi Zhou
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)