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Non-coding Genome in Small Cell Lung Cancer Between Theoretical View and Clinical Applications by Xiaomeng Yin; Jiqiao Yang; Hang Wang; Yuling Luo; Zeyi Qin; Lei Deng; Xuelei Ma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Non-coding Genome in Small Cell Lung Cancer Between Theoretical View and Clinical Applications about?

Small cell lung cancer (SCLC) is a highly aggressive cancer of the neuroendocrine system, characterized by poor differentiation, rapid growth, and poor overall survival (OS) of patients. Despite the recent advances in the treatment of SCLC recently, the 2-year survival rate of patients with the cancer is only 14-15%, occasioned by the acquired resistance to drugs and serious off-target effects. In humans, the coding region is only 2% of the total genome, and 20% of that is associated with human diseases. Beyond the coding genome are RNAs, promoters, enhancers, and other intricate elements. The non-coding regulatory regions, mainly the non-coding RNAs (ncRNAs), regulate numerous biological activities including cell proliferation, metastasis, and drug resistance. As such, they are potential diagnostic or prognostic biomarkers, and also potential therapeutic targets for SCLC. Therefore, understanding how non-coding elements regulate SCLC development and progression holds significant clinical implications. Herein, we summarized the recent discoveries on the relationship between the non-coding elements including long non-coding RNAs (lncRNA), microRNAs (miRNAs), circular RNA (circRNA),

Who reads Non-coding Genome in Small Cell Lung Cancer Between Theoretical View and Clinical Applications?

Author

Xiaomeng Yin; Jiqiao Yang; Hang Wang; Yuling Luo; Zeyi Qin; Lei Deng; Xuelei Ma

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)