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Targeted Co-delivery of a Photosensitizer and an Antisense Oligonucleotide Based on an Activatable Hyaluronic Acid Nanosystem with Endogenous Oxygen Generation for Enhanced Photodynamic Therapy of Hypoxic Tumors by Yanni Wu; Lei Ding; Cheng Zheng; Hongsheng Li; Ming Wu; Yupeng Sun; Xiaolong Liu; Xiaolong Zhang; Yongyi Zeng is a Engineering article available to read on EtoBox.
What is Targeted Co-delivery of a Photosensitizer and an Antisense Oligonucleotide Based on an Activatable Hyaluronic Acid Nanosystem with Endogenous Oxygen Generation for Enhanced Photodynamic Therapy of Hypoxic Tumors about?
Photodynamic therapy (PDT) is a promising cancer treatment modality with advantages of minimal invasiveness, repeatable therapy, and mild systemic toxicity. However, the limited bioavailability of photosensitizer (PS), tumor hypoxia, and the presence of antiapoptotic proteins in cancer cells, has hampered the efficiency of PDT. To address these limitations, herein, we developed a hyaluronic acid (HA) based nanosystem (HA-Ce6-Hemin@DNA-Protamine NPs, HCH@DP) loaded with chlorin e6 (Ce6, as PS), hemin (as mimetic catalase) and antisense oligonucleotide (ASO) of B-cell lymphoma 2 (Bcl-2) anti-apoptosis protein via a simple electrostatic self-assembly method for enhanced PDT of hypoxic solid tumors. The HCH@DP can target deliver the PS and ASO to tumor cells via cancer cell overexpressed HA receptors (i.e., CD44 or RHAMM). The Ce6 was released from HA-ss-Ce6 (HSC conjugates) after the reaction of cleavable disulfide bond with glutathione (GSH), which recovered the fluorescence and phototoxicity of Ce6 upon laser irradiation. Meanwhile, the catalase-mimicking hemin (degradation of HA-eda-hemin by hyaluronidase) decomposed the tumor overdressed endogenous HO to oxygen, which relieved tum
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- Author
- Yanni Wu; Lei Ding; Cheng Zheng; Hongsheng Li; Ming Wu; Yupeng Sun; Xiaolong Liu; Xiaolong Zhang; Yongyi Zeng
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)