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Can I read Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions on EtoBox?
Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions by Wetzels, Suzan ;Vanmierlo, Tim ;Scheijen, Jean L. J. M. ;van Horssen, Jack ;Amor, Sandra ;Somers, Veerle ;Schalkwijk, Casper G. ;Hendriks, Jerome J. A. ;Wouters, Kristiaan is a Immunology and Microbiology article available to read on EtoBox.
What is Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions about?
Multiple sclerosis (MS) is a demyelinating autoimmune disease in which innate and adaptive immune cells infiltrate the central nervous system (CNS) and damage the myelin sheaths surrounding the axons. Upon activation, infiltrated macrophages, CNS-resident microglia, and astrocytes switch their metabolism toward glycolysis, resulting in the formation of α-dicarbonyls, such as methylglyoxal (MGO) and glyoxal (GO). These potent glycating agents lead to the formation of advanced glycation endproducts (AGEs) after reaction with amino acids. We hypothesize that AGE levels are increased in MS lesions due to the inflammatory activation of macrophages and astrocytes. First, we measured tissue levels of AGEs in brain samples of MS patients and controls. Analysis of MS patient and non-demented control (NDC) specimens showed a significant increase in protein-bound N-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1), the major AGE, compared to white matter of NDCs (107 ± 11 vs. 154 ± 21, < 0.05). In addition, immunohistochemistry revealed that MGO-derived AGEs were specifically present in astrocytes, whereas the receptor for AGEs, RAGE, was detected on microglia/macrophages. Moreover, in c
Who reads Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Wetzels, Suzan ;Vanmierlo, Tim ;Scheijen, Jean L. J. M. ;van Horssen, Jack ;Amor, Sandra ;Somers, Veerle ;Schalkwijk, Casper G. ;Hendriks, Jerome J. A. ;Wouters, Kristiaan
- Publisher
- Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-3224)
- Published
- 2019
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)