About this Medicine article
275 ANTINOCICEPTIVE EFFECTS OF MORPHINE AFTER ACUTE AND REPEATED INJECTION IN WILD‐TYPE AND SIGMA‐1 RECEPTOR KNOCKOUT MICE by C. Sanchez Fernandez; E.J. Cobos; R. Gonzalez‐Cano; D. Zamanillo; E. Pozo del Gavilan is a Medicine article available to read on EtoBox.
Poster Sessions / European Journal of Pain 13 (2009) S55-S285 2, 4, 7, 10 and 14 days postoperatively, with a maximal expression at day 2 (476.5%; p < 0.001). KOR mRNA was up-regulated at days 2 and 14 (85.8% and 67.3%; p < 0.01, respectively). Surgery under sevoflurane also increased prodynorphin mRNA at days 7 and 14 (p < 0.05), and KOR mRNA at day 7 (p < 0.05), but to a lesser degree. In both groups, dynorphin levels were increased at 2, 4, 10 and 14 days after surgery but the global increase was higher in the remifentanil group (p < 0.05). Intraoperative remifentanil administration enhances and extents postoperative H/A and the expression of prodynorphin and KOR mRNA, and dynorphin in DRG. The study suggests that dynorphin at DRG may contribute to the development of postoperative pain sensitization.
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- Author
- C. Sanchez Fernandez; E.J. Cobos; R. Gonzalez‐Cano; D. Zamanillo; E. Pozo del Gavilan
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)