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Can I read P-quinone Mediates 6-Hydroxydopamine-induced Dopaminergic Neuronal Death and Ferrous Iron Accelerates the Conversion of P-quinone Into Melanin Extracellularly on EtoBox?
P-quinone Mediates 6-Hydroxydopamine-induced Dopaminergic Neuronal Death and Ferrous Iron Accelerates the Conversion of P-quinone Into Melanin Extracellularly by Yasuhiko Izumi; Hideyuki Sawada; Noriko Sakka; Noriyuki Yamamoto; Toshiaki Kume; Hiroshi Katsuki; Shun Shimohama; Akinori Akaike is a Neuroscience article available to read on EtoBox.
What is P-quinone Mediates 6-Hydroxydopamine-induced Dopaminergic Neuronal Death and Ferrous Iron Accelerates the Conversion of P-quinone Into Melanin Extracellularly about?
## Abstract Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). 6‐Hydroxydopamine (6‐OHDA), a dopaminergic neurotoxin, is detected in human brains and the urine of PD patients. Using SH‐SY5Y, a human neuroblastoma cell line, we demonstrated that 6‐OHDA toxicity was determined by the amount of __p__‐quinone produced in 6‐OHDA auto‐oxidation rather than by reactive oxygen species (ROS). Glutathione (GSH), which conjugated with __p__‐quinone, provided significant protection whereas catalase, which detoxified hydrogen peroxide and superoxide anions, failed to block cell death caused by 6‐OHDA. Although iron accumulated in the SN of patients with PD can cause dopaminergic neuronal degeneration by enhancing oxidative stress, we found that extracellular ferrous iron promoted the formation of melanin and reduced the amount of __p__‐quinone. The addition of ferrous iron to the culture medium inhibited caspase‐3 activation and apoptotic nuclear morphologic changes and blocked 6‐OHDA‐induced cytotoxicity in SH‐SY5Y cells and primary cultured mesencephalic dopaminergic neurons. These data suggested that generation of __p__‐quino
Who reads P-quinone Mediates 6-Hydroxydopamine-induced Dopaminergic Neuronal Death and Ferrous Iron Accelerates the Conversion of P-quinone Into Melanin Extracellularly?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yasuhiko Izumi; Hideyuki Sawada; Noriko Sakka; Noriyuki Yamamoto; Toshiaki Kume; Hiroshi Katsuki; Shun Shimohama; Akinori Akaike
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2005
- Language
- EN
- Field
- Neuroscience (Life Sciences)