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Expression of members of the miRNA17–92 cluster during development and in carcinogenesis by Anne-Marthe Jevnaker; Cuong Khuu; Elisabeth Kjøle; Magne Bryne; Harald Osmundsen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The six microRNAs (miRNA) encoded by the miR‐17–92 cluster, also named oncomir‐1, have been associated with carcinogenesis and typically exhibit‐increased expression in tumors. Despite the well‐established role for the miR‐17–92 cluster in an oncogenic network, the physiological function of these miRNAs in normal tissues remains unresolved. In order to investigate whether there are similar patterns of miR‐17–92 expression during embryogenesis and carcinogenesis, we have preformed a systematic study of the expression in cultured carcinoma cells, cultured primary human keratinocytes (KC), and during development of some murine tissues. Both levels of expression of the primary transcript (pri‐miRNA) and levels of expression of the individual members of the cluster were monitored. Irrespectively of tissue examined we found that the level of expression decreased markedly during development. With cultured primary human KCs their levels of expression of some of these microRNAs decreased as the number of cell passages increased. Their levels of expression in cultured carcinoma cells, in contrasts, increased, or remained unchanged, with increasing number of cell passages. The res

Who reads Expression of members of the miRNA17–92 cluster during development and in carcinogenesis?

Author

Anne-Marthe Jevnaker; Cuong Khuu; Elisabeth Kjøle; Magne Bryne; Harald Osmundsen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)