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Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography by Taketoshi Asanuma; Sabrina Doblas; Yasvir A. Tesiram; Debra Saunders; Rebecca Cranford; Hironobu Yasui; Osamu Inanami; Nataliya Smith; Robert A. Floyd; Yashige Kotake; Rheal A. Towner is a Medicine article available to read on EtoBox.

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## Abstract ## Purpose To apply fiber tractography to assess the effect of a possible antiglioma drug, phenyl __N‐tert__‐butyl nitrone (PBN), on glioma‐affected neuronal fibers. The fiber tractography method was able to differentiate between different tumor types, such as the C6 and F98 rat glioma models. ## Materials and Methods C6 or F98 cells were intracranially injected into the cortex of male Fischer 344 rats. PBN treatment was initiated before or after cell implantation. Tumor growth was monitored with diffusion tensor imaging (DTI) and fiber tractography using diffusion‐weighting gradients in 30 noncolinear directions. ## Results Although proton density‐weighted (PDw) and T2‐weighted (T2w) images did not show any difference between C6 and F98 gliomas without edema, the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were able to discriminate between these two tumor models. Fiber tractography was used to visualize C6 glioma‐induced ischemia of tumor‐surrounding tissues, whereas F98 glioma was found to infiltrate and penetrate into the corpus callosum (CC). During glioma growth, neuronal fibers were found to disappear at the border regions between the

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Author

Taketoshi Asanuma; Sabrina Doblas; Yasvir A. Tesiram; Debra Saunders; Rebecca Cranford; Hironobu Yasui; Osamu Inanami; Nataliya Smith; Robert A. Floyd; Yashige Kotake; Rheal A. Towner

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2008

Language

EN

Field

Medicine (Health Sciences)