Opening book details…
Can I read Preliminary evaluation of [^18^F]AlF-NOTA-MAL-Cys^39^-exendin-4 in insulinoma with PET on EtoBox?
Preliminary evaluation of [^18^F]AlF-NOTA-MAL-Cys^39^-exendin-4 in insulinoma with PET by Qing Xu; Chen Zhu; Yuping Xu; Donghui Pan; Ping Liu; Runlin Yang; Lizhen Wang; Fei Chen; Xinchen Sun; Shineng Luo; Min Yang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Preliminary evaluation of [^18^F]AlF-NOTA-MAL-Cys^39^-exendin-4 in insulinoma with PET about?
## Background: High expression of glucagon-like peptide-1 receptor (glp-1r) in insulinoma supplies a potential drug target for tumor imaging. exendin-4 can specifically bind to glp-1r as an agonist and its analogs are extensively used in receptor imaging studies. ## Purpose: A new glp-1r imaging agent, [(18)f]alf-nota-mal-cys(39)-exendin-4, was designed and prepared for insulinoma imaging. ## Methods: Cys(39)-exendin-4 was conjugated with nota-mal, then the compound was radiolabeled with [(18)f]alf complex to obtained [(18)f]alf-nota-mal-cys(39)-exendin-4. the tumor-targeting characters of the tracer were evaluated in ins-1 cells and balb/c nude mice models. ## Results: [(18)f]alf-nota-mal-cys(39)-exendin-4 can be efficiently produced with a yield of 17.5 ± 3.2% (non-decay corrected) and radiochemical purity of >95%. the ic50 value of displacement [(18)f]alf-nota-mal-cys(39)-exendin-4 with cys(39)-exendin-4 was 13.52 ± 1.36 nm. pet images showed excellent tumor visualization with high uptake (9.15 ± 1.6%id/g at 30 min and 7.74 ± 0.87%id/g at 60 min). the tumor to muscle, pancreas and liver ratios were 63.25, 3.85 and 7.29 at 60 min after injection. glp-1r binding specificity was de
Who reads Preliminary evaluation of [^18^F]AlF-NOTA-MAL-Cys^39^-exendin-4 in insulinoma with PET?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Qing Xu; Chen Zhu; Yuping Xu; Donghui Pan; Ping Liu; Runlin Yang; Lizhen Wang; Fei Chen; Xinchen Sun; Shineng Luo; Min Yang
- Publisher
- Informa UK Limited
- Published
- 2015
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)