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Can I read 5-Azacitidine Restores and Amplifies the Bicalutamide Response on Preclinical Models of Androgen Receptor Expressing or Deficient Prostate Tumors on EtoBox?
5-Azacitidine Restores and Amplifies the Bicalutamide Response on Preclinical Models of Androgen Receptor Expressing or Deficient Prostate Tumors by Giovanni Luca Gravina; Francesco Marampon; Mario Di Staso; Pierluigi Bonfili; Alessandro Vitturini; Emmanuele A. Jannini; Richard G. Pestell; Vincenzo Tombolini; Claudio Festuccia is a Medicine article available to read on EtoBox.
What is 5-Azacitidine Restores and Amplifies the Bicalutamide Response on Preclinical Models of Androgen Receptor Expressing or Deficient Prostate Tumors about?
## Abstract ## BACKGROUND Epigenetic modifications play a key role in the in prostate cancer (Pca) progression to a hormone refractory state (HRPC) and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. In this regard, 5‐Azacitine (5‐Aza) represents a promising epigenetic modulator. This study tested the hypothesis that 5‐Aza may restore and enhance the responsiveness of HRPC cells to anti‐hormonal therapy on Androgen receptor (AR) expressing (22rv1) and AR‐deficient (PC3) cells. ## METHODS The effects were studied in vitro and in vivo models. This sequential treatment induced in vitro cell cycle arrest and apoptosis both in 22rv1 and PC3 tumor cell lines. ## RESULTS This combined treatment up‐regulated the expression of FasL, phospho‐FADD, p16^INKA^, Bax, Bak, and p21^WAF1^, and inhibited FLIP, Bcl‐2, and Bcl‐XL expression. The re‐activation of hormonal response of AR‐negative PC3 cell line was partially due to the AR re‐expression mediated by 5‐Aza treatment. In contrast, the increase in the response to anti‐androgenic therapy in 22rv1 did not correlate with AR expression levels. Furthermore, xenograft studies reveale
Who reads 5-Azacitidine Restores and Amplifies the Bicalutamide Response on Preclinical Models of Androgen Receptor Expressing or Deficient Prostate Tumors?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Giovanni Luca Gravina; Francesco Marampon; Mario Di Staso; Pierluigi Bonfili; Alessandro Vitturini; Emmanuele A. Jannini; Richard G. Pestell; Vincenzo Tombolini; Claudio Festuccia
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)