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Can I read Homozygous Machado–Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms on EtoBox?
Homozygous Machado–Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms by T. Fukutake; H. Shinotoh; H. Nishino; Y. Ichikawa; J. Goto; I. Kanazawa; T. Hattori is a Medicine article available to read on EtoBox.
What is Homozygous Machado–Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms about?
A male patient carrying the homozygous gene for Machado–Joseph disease (MJD) presented at age 43 with sleep disturbances and psychiatric symptoms followed by ataxic speech and gait. A polysomnogram (PSG) showed decreased rates of sleep time and stage rapid eye movement (REM) and an increased rate of ‘stage 1‐REM with tonic EMG’ (Tachibana __et al__., 1975); all compatible with REM sleep behaviour disorder (RBD). Molecular gene analysis at age 59 showed that the CAG repeat units in the __MJD__ gene were 60 and 60, smaller than the reported lengths for homozygous MJD patients (63–70 and 66–72). In addition to sleep disturbances, in particular RBD, psychiatric symptoms may be important clinical features in both heterozygous and homozygous MJD.
Who reads Homozygous Machado–Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- T. Fukutake; H. Shinotoh; H. Nishino; Y. Ichikawa; J. Goto; I. Kanazawa; T. Hattori
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1351-5101)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)