Opening book details…
Can I read Impaired Ca2+ mobilization by X-linked agammaglobulinaemia (XLA) B cells in response to ligation of the B cell receptor (BCR) on EtoBox?
Impaired Ca2+ mobilization by X-linked agammaglobulinaemia (XLA) B cells in response to ligation of the B cell receptor (BCR) by H. C. GENEVIER; R. E. CALLARD is a Immunology and Microbiology article available to read on EtoBox.
What is Impaired Ca2+ mobilization by X-linked agammaglobulinaemia (XLA) B cells in response to ligation of the B cell receptor (BCR) about?
## SUMMARY XLA bone marrow samples were shown to contain B cells expressing IgM, and pre-B cells that express the μ-surrogate light chain (μψLC) complex, albeit at a reduced frequency to that found in normal bone marrow. Antibody ligation of μ heavy chain on these cells and an XLA B cell line did not induce a Ca2+ flux, whereas ligation of μ heavy chain on normal bone marrow cells, μψLC+ pre-B cell lines and an IgM+ B cell line did. The block in XLA B cells was not due to a defect in the basic mechanism of Ca2+ flux generation, as the cells responded well to thapsigargin. In addition, the defect did not affect T cells, which were shown to respond to CD3 antibody with a Ca2+ flux. Ligation of μ heavy chain on XLA bone marrow cells did, however, activate tyrosine kinases, resulting in tyrosine phosphorylation of a cellular protein with a molecular weight of approximately 115 kD. These results indicate that Btk may be necessary for the generation of the Ca2+ flux in response to ligation of μ heavy chain on B cells and μψLC+ pre-B.
Who reads Impaired Ca2+ mobilization by X-linked agammaglobulinaemia (XLA) B cells in response to ligation of the B cell receptor (BCR)?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- H. C. GENEVIER; R. E. CALLARD
- Publisher
- Oxford University Press (OUP)
- Published
- 1997
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)