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Kunxian Capsule for Rheumatoid Arthritis: Inhibition of Inflammatory Network and Reducing Adverse Reactions Through Drug Matching by Tang, Yujun; Zhang, Yi; Li, Lin; Xie, Zhijun; Wen, Chengping; Huang, Lin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Kunxian Capsule for Rheumatoid Arthritis: Inhibition of Inflammatory Network and Reducing Adverse Reactions Through Drug Matching about?

__Tripterygium wilfordii Hook.f__ and __Tripterygium hypoglaucum (H.Lév.) Hutch__ is effective herbs to prevent aggravation of Rheumatoid arthritis (RA). However, both of them show severe side effects in the reproductive system and other systems. Kunxian Capsule (KX), a Traditional Chinese Medicine (TCM) patent prescription, comprised of 4 herbs, including __H.Lév. Hutch__, is reported to be an available prescription in treating RA with fewer side effects as compares to Tripterygium tablets. To reveal the pharmacological mechanism of KX in RA treatment and side effect alleviation, we collected related information of KX from open-access databases and performed various analyses. 1354 targets were identified in KX. These targets were enriched in the calcium signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway and PI3K-AKT signaling pathway, forming biological functions, such as cofactor binding, coenzyme binding, etc. These pathways or functions mostly affect cell cycle, differentiation, and maturation of Th17 cells, macrophage, and synovial fibroblast. These targets also act on the IL-17 signaling pathway, Th17 cell differentiation signaling pathway and TNF signaling

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Author

Tang, Yujun; Zhang, Yi; Li, Lin; Xie, Zhijun; Wen, Chengping; Huang, Lin

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1663-9812)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)