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Can I read Structural Insights for β-Lactam Antibiotics on EtoBox?
Structural Insights for β-Lactam Antibiotics by Dogyeoung Kim; Sumin Kim; Yongdae Kwon; Yeseul Kim; Hyunjae Park; Kiwoong Kwak; Hyeonmin Lee; Jung Hun Lee; Kyung-Min Jang; Donghak Kim; Sang Hee Lee; Lin-Woo Kang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structural Insights for β-Lactam Antibiotics about?
Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.
Who reads Structural Insights for β-Lactam Antibiotics?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dogyeoung Kim; Sumin Kim; Yongdae Kwon; Yeseul Kim; Hyunjae Park; Kiwoong Kwak; Hyeonmin Lee; Jung Hun Lee; Kyung-Min Jang; Donghak Kim; Sang Hee Lee; Lin-Woo Kang
- Publisher
- The Korean Society of Applied Pharmacology
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)