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Clinical Significance of Pleural Effusion Mesothelin in Malignant Pleural Mesothelioma by Shusai Yamada; Chiharu Tabata; Rie Tabata; Kazuya Fukuoka; Takashi Nakano is a Medicine article available to read on EtoBox.

What is Clinical Significance of Pleural Effusion Mesothelin in Malignant Pleural Mesothelioma about?

## Background: Malignant pleural mesothelioma (mpm) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. mpm has a limited response to conventional chemotherapy and radiotherapy, so early diagnosis of mpm is very important. this study investigated the pleural effusion mesothelin levels in patients with mpm and compared them to those of a population with a non-malignant pleuritis or lung cancer involving malignant pleural effusion. ## Methods: The pleural effusion mesothelin concentrations were measured in 45 mpm patients and 53 non-mpm individuals (24 individuals with non-malignant pleural effusions and 29 individuals with lung cancer involving malignant pleural effusion). ## Results: This study demonstrated that patients with mpm had significantly higher pleural effusion mesothelin levels than a population with non-malignant pleuritis or lung cancer involving malignant pleural effusion. the difference in overall survival between the groups with pleural effusion mesothelin levels lower and higher than the assumed cut-off of 10 nm was significant. ## Conclusions: The data suggest that the pleural effusion mesothelin concentration could be useful

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Author

Shusai Yamada; Chiharu Tabata; Rie Tabata; Kazuya Fukuoka; Takashi Nakano

Publisher

Walter de Gruyter GmbH

Published

2011

Language

EN

Field

Medicine (Health Sciences)