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Quantitative determination of diclofenac sodium in solid dosage forms by FT-Raman spectroscopy by Sylwester Mazurek; Roman Szostak is a Chemistry article available to read on EtoBox.
What is Quantitative determination of diclofenac sodium in solid dosage forms by FT-Raman spectroscopy about?
The FT-Raman quantification of diclofenac sodium in tablets and capsules was performed with the help of the partial least squares (PLS), principal component regression (PCR) and counter-propagation artificial neural networks (CP-ANN) methods. For the analysed tablets, calibration models were built using unnormalised spectra and spectra normalised by the intensity of a selected band of an internal standard. Different pre-processing methods were applied for the capsules. To compare the predictive ability of the models, the relative standard errors of prediction (RSEP) were calculated. The 5 × 5 CP-ANN and PLS methods gave models of comparable quality, which were usually more efficient than the PCR ones. The RSEP error values for the tablets were in the range of 2.4-3.8% for the calibration and 2.6-3.5% for the validation data sets and for the three procedures applied. For capsules, the RSEP errors were in the range of 0.8-1.9% and 1.4-1.7% for the calibration and validation samples, respectively. Five commercial products containing 25, 50 or 75 mg of diclofenac sodium per tablet/capsule were quantified. Concentrations found from the Raman data analysis agree with the results of the r
Who reads Quantitative determination of diclofenac sodium in solid dosage forms by FT-Raman spectroscopy?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Sylwester Mazurek; Roman Szostak
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)