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The Development of Chiral Nanoparticles to Target NK Cells and CD8^+^ T Cells for Cancer Immunotherapy by Weiwei Wang; Jing Zhao; Changlong Hao; Shudong Hu; Chen Chen; Yi Cao; Zhengyu Xu; Jun Guo; Liguang Xu; Maozhong Sun; Chuanlai Xu; Hua Kuang is a Engineering article available to read on EtoBox.
What is The Development of Chiral Nanoparticles to Target NK Cells and CD8^+^ T Cells for Cancer Immunotherapy about?
## Abstract The chirality of nanomaterials (nanoparticles, NPs) can influence their interaction with cells and biological systems. However, how chirality can exert impact on the immune response has yet to be investigated. Here, the immunological effect of chiral nanomaterials is investigated as a therapeutic and preventive option against tumors. Compared with achiral nanoparticles, chiral NPs with a g‐factor of 0.44 are shown to enhance both innate and acquired immunity against tumor growth. It is also found that chiral NPs enhance the activation of CD8^+^ T and natural killer cells (CD69^+^ NK cells) by stimulating dendritic cells (DCs). Importantly, L‐type NPs induce a 1.65‐fold higher proportion of CD8^+^ T and CD69^+^ NK cells than D‐type NPs. Next, the therapeutic and preventative effects of chiral NPs against tumors in a EG7.OVA tumor model are investigated. It is found that L‐type NPs have a significant greater ability to induce apoptosis in tumor cells and prolong the survival time of model mice than D‐type NPs. Mice treated with L‐type NPs induce the activation of 84.98 ± 6.63% CD8^+^ T cells and 33.62 ± 3.41% of NK cells in tumor tissues; these are 1.62‐fold and 1.39‐fold
Who reads The Development of Chiral Nanoparticles to Target NK Cells and CD8^+^ T Cells for Cancer Immunotherapy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Weiwei Wang; Jing Zhao; Changlong Hao; Shudong Hu; Chen Chen; Yi Cao; Zhengyu Xu; Jun Guo; Liguang Xu; Maozhong Sun; Chuanlai Xu; Hua Kuang
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)