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What is Understanding Sickle Cell Anemia: Causes & Management about?

1. Sickle cell anemia is caused by a mutation in the beta-globin gene that results in abnormal sickle-shaped red blood cells. 2. When deoxygenated, sickle hemoglobin molecules polymerize within red blood cells, causing them to take on a sickle shape and become rigid. This leads to hemolysis and vaso-occlusion. 3. Management of sickle cell disease involves health maintenance including vaccination, screening and treatment of complications like infection, pain crises, acute chest syndrome, and stroke.

Author

sakthi

Language

EN