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The Activities of Tissue Xanthine Oxidase and Adenosine Deaminase and the Levels of Hydroxyproline and Nitric Oxide in Rat Hearts Subjected to Doxorubicin: Protective Effect of Erdosteine by Ersin Fadillioglu; H.Ramazan Yılmaz; Hasan Erdogan; Sadik Sogut is a Environmental Science article available to read on EtoBox.

What is The Activities of Tissue Xanthine Oxidase and Adenosine Deaminase and the Levels of Hydroxyproline and Nitric Oxide in Rat Hearts Subjected to Doxorubicin: Protective Effect of Erdosteine about?

The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats. Rats were treated with erdosteine (10 mg/kg b.wt. per day, orally) or saline starting 2 days before administrating a single dose of DXR (20 mg/kg i.p.) or saline. At the 10th day of the DXR administration, hearts were removed under anesthesia for biochemical measurements. Enzyme activities as well as OHproline and NO levels were found to be significantly increased in DXR group compared with the control group. All of the parameters studied except ADA activity were decreased significantly approximating to the control levels upon erdosteine administration. In conclusion, erdosteine seems to be an alternative agent for protection of cardiac tissue against DXR-induced cardio-toxicity through its regulatory effect on XO activity and NO level.

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Author

Ersin Fadillioglu; H.Ramazan Yılmaz; Hasan Erdogan; Sadik Sogut

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2003

Language

EN

Field

Environmental Science (Life Sciences)