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Can I read Design of Lipid Nanoparticles for the Oral Delivery of Hydrophilic Macromolecules on EtoBox?
Design of Lipid Nanoparticles for the Oral Delivery of Hydrophilic Macromolecules by M Garcı́a-Fuentes; D Torres; M.J Alonso is a Materials Science article available to read on EtoBox.
What is Design of Lipid Nanoparticles for the Oral Delivery of Hydrophilic Macromolecules about?
Colloidal drug carriers prepared from solid triglycerides have been presented as a promising alternative to polymer nanoparticles. The present work is aimed at developing surface-modified lipid nanoparticles intended to encapsulate peptides within their structure and to study their physicochemical properties and in vitro stability in gastrointestinal fluids. The final goal is to explore their potential as oral delivery vehicles for macromolecules. The W/O/W multiple emulsion technique was originally applied and conveniently modified for the production of tripalmitin nanoparticles. This technique was selected because its makes the encapsulation of peptides feasible. Additionally, the surface of the particles could be modified through the incorporation of Poloxamer 188 or the lipid derivative PEG 2000-stearate into the formulation. This modification led to a reduction in the zeta potential values, varying from (/34 mV for the noncoated particles to (/20 mV for those prepared with PEG-stearate. Results of the stability of the nanoparticles in gastric and intestinal media indicate that the low pH of the gastric medium and the pancreatic enzymes in intestinal medium are responsible for
Who reads Design of Lipid Nanoparticles for the Oral Delivery of Hydrophilic Macromolecules?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- M Garcı́a-Fuentes; D Torres; M.J Alonso
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)
- Published
- 2003
- Language
- EN
- Field
- Materials Science (Physical Sciences)