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Immunohistological Studies on Macrophages in Lymph Nodes of Onchocerciasis Patients After Treatment with Ivermectin by Julia Knab; Kassa Darge; D.W. Büttner is a Medicine article available to read on EtoBox.

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## Summary The role of macrophages in the killing and elimination of microfilariae (mf) was studied immunohistologically in 14 lymph nodes from 10 patients with generalized onchocerciasis 20–68 h after treatment with a single oral dose of 150 μg/kg ivermectin. Mf with signs of damage at light microscopical level were surrounded by a cellular infiltrate comprising macrophages, eosinophils and neutrophils, whereas light microscopically intact mf mostly showed no cellular reaction. Resident mature macrophages expressing the CD 68 epitope usually neither migrated nor attached to damaged mf, especially on the first and second day after ivermectin treatment. However, many young invading macrophages labelled for the L1 protein (antibodies 27 E 10, MAC 387, S 36.48 and 8.5C2) were found within the cellular infiltrate around damaged mf and in adherence to the mf in all lymph nodes after ivermectin treatment. Free L1 protein was observed on the cuticle of the mf. The attacking macrophages contained increased amounts of the enzymes lysozyme, α‐1‐antichymotrypsin and α‐1‐antitrypsin compared to resident macrophages. Free enzymes were found on the cuticle of the mf and around them, indicating a

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Author

Julia Knab; Kassa Darge; D.W. Büttner

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; ScienceOpen (ISSN 1360-2276)

Published

1997

Language

EN

Field

Medicine (Health Sciences)