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Bcl-2 and Bak May Play a Pivotal Role in Sodium Butyrate-induced Apoptosis in Colonic Epithelial Cells; However Overexpression of Bcl-2 Does Not Protect Against Bak-mediated Apoptosis by Angela Hague; G. Darío Díaz; Diane J. Hicks; Stanislaw Krajewski; John C. Reed; Christos Paraskeva is a Medicine article available to read on EtoBox.
What is Bcl-2 and Bak May Play a Pivotal Role in Sodium Butyrate-induced Apoptosis in Colonic Epithelial Cells; However Overexpression of Bcl-2 Does Not Protect Against Bak-mediated Apoptosis about?
Butyrate, a short chain fatty acid produced in the colon as a result of fermentation of dietary fibre by symbiotic bacteria, induces apoptosis in colonic tumour cell lines. Three human colonic adenoma cell lines (AA/C1, RG/C2 and BH/C1) and one carcinoma cell line (S/KS/FI) were used to determine the effects of butyrate on the expression of bcl-2, bax and bak to examine the possible role of these proteins in the induction of apoptosis. RG/C2 and BH/C1 cells express p-26-bcl-2 and butyrate treatment decreased p26-bcl-2 levels in association with apoptosis, whereas bax and bak levels remained constant. AA/C1 and S/KS/FI cells have no detectable p26-bcl-2. In S/KS/FI cells, bax or bak levels did not change in response to butyrate. However, in AA/C1 cells, butyrate-induced apoptosis was associated with increased bak levels. Therefore, in AA/C1 cells butyrate-induced apoptosis appears to be mediated through bak. Furthermore, butyrate also induced apoptosis and increased bak levels in AA/C1 cells transfected with a bcl-2 expression vector which expressed high levels of p26-bcl-2. For S/KS/FI cells, two bcl-2 transfectants gave different results. bcl-2 protected against apoptosis in one t
Who reads Bcl-2 and Bak May Play a Pivotal Role in Sodium Butyrate-induced Apoptosis in Colonic Epithelial Cells; However Overexpression of Bcl-2 Does Not Protect Against Bak-mediated Apoptosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Angela Hague; G. Darío Díaz; Diane J. Hicks; Stanislaw Krajewski; John C. Reed; Christos Paraskeva
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)