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Can I read Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease on EtoBox?
Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease by Jiho Sohn; Lu Li; Lixia Zhang; Robert J. Genco; Karen L. Falkner; Hervé Tettelin; Aryn M. Rowsam; Dominic J. Smiraglia; Jan M. Novak; Patricia I. Diaz; Yijun Sun; Keith L. Kirkwood is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease about?
## SUMMARY Intestinal colonization of the oral bacterium __Haemophilus parainfluenzae__ has been associated with Crohn’s disease (CD) severity and progression. This study examines the role of periodontal disease (PD) as a modifier for colonization of __H. parainfluenzae__ in patients with CD and explores the mechanisms behind __H. parainfluenzae__-mediated intestinal inflammation. Fifty subjects with and without CD were evaluated for the presence of PD, and their oral and fecal microbiomes were characterized. PD is associated with increased levels of __H. parainfluenzae__ strains in subjects with CD. Oral inoculation of __H. parainfluenzae__ elicits strain-dependent intestinal inflammation in murine models of inflammatory bowel disease, which is associated with increased intestinal interferon-γ (IFN-γ)+ CD4+ T cells and disruption of the host hypusination pathway. In summary, this study establishes a strain-specific pathogenic role of __H. parainfluenzae__ in intestinal inflammation and highlights the potential effect of PD on intestinal colonization by pathogenic __H. parainfluenzae__ strains in patients with CD.
Who reads Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jiho Sohn; Lu Li; Lixia Zhang; Robert J. Genco; Karen L. Falkner; Hervé Tettelin; Aryn M. Rowsam; Dominic J. Smiraglia; Jan M. Novak; Patricia I. Diaz; Yijun Sun; Keith L. Kirkwood
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)