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Long-term functional consequences of transient occlusion of the middle cerebral artery in rats:: A 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits by Heli Karhunen; Asla Pitkänen; Tiina Virtanen; Irina Gureviciene; Raimo Pussinen; Aarne Ylinen; Juhani Sivenius; Jari Nissinen; Jukka Jolkkonen is a Medicine article available to read on EtoBox.

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Post-stroke seizures occur in 5-20% of patients. Modeling of stroke-induced seizures in animals provides a useful tool for investigating the molecular basis of epileptogenesis and for developing therapies for stroke patients at increased risk for epileptogenesis. The questions addressed in the study were: (1) Do rats develop spontaneous seizures after transient occlusion of the middle cerebral artery (MCAO)? (2) Is epileptogenesis associated with impaired hippocampus-dependent spatial learning and memory? (3) Are the functional abnormalities linked to axonal plasticity in the dentate gyrus? (4) Does the sensorimotor impairment induced by MCAO predict the risk of epileptogenesis? Adult male Sprague-Dawley rats were subjected to MCAO for 120 min. Development of spontaneous seizures was monitored by 1 week of continuous video-electroencephalographic (EEG) recordings at 3, 7, and 12 months after MCAO. Spontaneous seizures were not detected during 1-year follow-up in ischemic rats. Animals were, however, impaired in the spatial memory task (P<0.001), which was not associated with altered hippocampal LTP or abnormal mossy fiber sprouting (Timm staining). Animals also had a long-lasting s

Who reads Long-term functional consequences of transient occlusion of the middle cerebral artery in rats:: A 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits?

Author

Heli Karhunen; Asla Pitkänen; Tiina Virtanen; Irina Gureviciene; Raimo Pussinen; Aarne Ylinen; Juhani Sivenius; Jari Nissinen; Jukka Jolkkonen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2003

Language

EN

Field

Medicine (Health Sciences)