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Contents of Volumes in the Metal Ions in Life Sciences Series by Sigel, Astrid; Sigel, Helmut; Freisinger, Eva; Sigel, Roland K.O.; Riddell, Imogen; Lippard, Stephen J.; Brabec, Victor; Kasparkova, Jana; Menon, Vijay; Farrell, Nicholas P.; Venkatesh, V.; Sadler, Peter J.; Gorle, Anil K.; Peterson, Erica J.; Berners-Price, Susan; Alessio, Enzo; Messori, Luigi; Babak, Maria V.; Ang, Wee Han; Casini, Angela; Sun, Raymond Wai-Yin; Ott, Ingo; Tshuva, Edit; Miller, Maya; Crans, Debbie; Yan, Lining; Haase, Allison; Yang, Xiaogai; Chitambar, Christopher; Cardo, Lucia; Hannon, Michael John; Vilar, Ramon; Sullivan, Matthew P.; Holtkamp, Hannah U.; Hartinger, Christian G.; Schatzschneider, Ulrich; Thévenod, Frank; Denoyer, Delphine; Clatworthy, Sharnel A. S.; Cater, Michael; Ziliotto, Silvia; Ogle, Olivia; Taylor, Kathryn M. is a scholarly article available to read on EtoBox.

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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry,

Author

Sigel, Astrid; Sigel, Helmut; Freisinger, Eva; Sigel, Roland K.O.; Riddell, Imogen; Lippard, Stephen J.; Brabec, Victor; Kasparkova, Jana; Menon, Vijay; Farrell, Nicholas P.; Venkatesh, V.; Sadler, Peter J.; Gorle, Anil K.; Peterson, Erica J.; Berners-Price, Susan; Alessio, Enzo; Messori, Luigi; Babak, Maria V.; Ang, Wee Han; Casini, Angela; Sun, Raymond Wai-Yin; Ott, Ingo; Tshuva, Edit; Miller, Maya; Crans, Debbie; Yan, Lining; Haase, Allison; Yang, Xiaogai; Chitambar, Christopher; Cardo, Lucia; Hannon, Michael John; Vilar, Ramon; Sullivan, Matthew P.; Holtkamp, Hannah U.; Hartinger, Christian G.; Schatzschneider, Ulrich; Thévenod, Frank; Denoyer, Delphine; Clatworthy, Sharnel A. S.; Cater, Michael; Ziliotto, Silvia; Ogle, Olivia; Taylor, Kathryn M.

Publisher

Walter De Gruyter Gmbh & Co Kg

Published

2018

Language

EN

ISBN

9783110470741