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Marked Increase in Etravirine and Saquinavir Plasma Concentrations During Atovaquone/proguanil Prophylaxis by Chiara Tommasi; Rita Bellagamba; Massimo Tempestilli; Antonio D’Avolio; Anna L Gallo; Jelena Ivanovic; Emanuele Nicastri; Leopoldo P Pucillo; Pasquale Narciso is a Medicine article available to read on EtoBox.
What is Marked Increase in Etravirine and Saquinavir Plasma Concentrations During Atovaquone/proguanil Prophylaxis about?
The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450.
Who reads Marked Increase in Etravirine and Saquinavir Plasma Concentrations During Atovaquone/proguanil Prophylaxis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chiara Tommasi; Rita Bellagamba; Massimo Tempestilli; Antonio D’Avolio; Anna L Gallo; Jelena Ivanovic; Emanuele Nicastri; Leopoldo P Pucillo; Pasquale Narciso
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Research Square (ISSN 1475-2875)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)